Beilstein J. Org. Chem.2019,15, 469–473, doi:10.3762/bjoc.15.40
phosphorus atoms was synthesized by the microwave-assisted and catalyst-free Kabachnik–Fields reaction of (aminomethyl)phosphineoxides with paraformaldehyde and diphenylphosphine oxide. The three-component condensation of N,N-bis(phosphinoylmethyl)amine, paraformaldehyde and a secondary phosphine oxide
affording N,N,N-tris(phosphinoylmethyl)amine derivatives was also elaborated. This method is a novel approach for the synthesis of the target products.
Keywords: (aminomethyl)phosphineoxides; Kabachnik–Fields reaction; ligand; microwave; N,N-bis(phosphinoylmethyl)amines; N,N,N-tris(phosphinoylmethyl
elaborated by us for the synthesis of several (aminomethyl)phosphineoxides [10][11].
As regards α-aminophosphine oxides with different P-substituents, only two different types were reported. Olszewski and co-workers synthesized chiral thiazole-substituted aminophosphine oxides 2 through the Pudovik reaction
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Graphical Abstract
Scheme 1:
Synthesis of chiral thiazole-substituted aminophosphine oxides.